Expression and function of the neurotransmitter serotonin during development of the Helisoma nervous system

摘要: Exogenous serotonin has been shown to evoke a neuron-selective inhibition of neurite outgrowth and synaptogenesis in identified Helisoma neurons vitro. We demonstrate here that is present the embryonic nervous system can act as regulator neuronal development vivo Serotonin-like immunoreactivity was first observed at an early stage (E20). Throughout embryogenesis, number serotonin-immunoreactive increased stereotypic pattern unique for each type ganglion. Strikingly, continued increase throughout adult life. Transient perturbation endogenous levels during embryogenesis had profound effects on specific neurons. Embryos treated with 5,7-dihydroxytryptamine raised maturity showed aberrations morphology, dye coupling, strength electrical synaptic connections. These were restricted known be sensitive growth-inhibitory results support hypothesis neurotransmitters are important class regulatory factors normal system.