Different transcriptional levels of GABAA receptor subunits in mouse cumulus cells around oocytes at different mature stage.
作者： Huangguan Dai , Cuifang Hao , Xin Huang , Zhenteng Liu , Huayu Lian
DOI: 10.1080/09513590.2016.1197198
关键词: GABA receptor 、 Oocyte 、 Endocrinology 、 Germinal vesicle 、 GABAA receptor 、 Internal medicine 、 Central nervous system 、 Oogenesis 、 Biology 、 Cell biology 、 Receptor 、 Polycystic ovary
摘要: γ-Aminobutyric acid (GABA) is a principal inhibitory neurotransmitter in the central nervous system (CNS) of vertebrates. However, GABA and its receptor are found not only peripheral neuronal tissue but also many nonneuronal tissues, thought to have multiple physiological functions. The bidirectional communication between oocytes cumulus cells (CCs) plays significant role oocyte maturation metabolism. In our previously study, expression level α5 subunit CCs isolated from patients with polycystic ovary syndrome had been be associated nuclear maturity. this we investigated transcriptional levels GABAA subunits germinal vesicle (GV) metaphase II (MII) mouse CCs, explored GABA-A during ovarian follicular development maturation. We that exhibited differential at different maturity stages. It suggested an involvement related certain
sci-hub.se 参考文章(26)
H‐J Feng, Y Jounaidi, M Haburcak, X Yang, S A Forman, Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABAA receptors British Journal of Pharmacology. ,vol. 171, pp. 789- 798 ,(2014) , 10.1111/BPH.12507
Masahito Watanabe, Kentaro Maemura, Kiyoto Kanbara, Takumi Tamayama, Hana Hayasaki, GABA and GABA receptors in the central nervous system and other organs. International Review of Cytology-a Survey of Cell Biology. ,vol. 213, pp. 1- 47 ,(2002) , 10.1016/S0074-7696(02)13011-7
Wei Jian Zhu, Jian Feng Wang, Karl E. Krueger, Stefano Vicini, δ Subunit Inhibits Neurosteroid Modulation of GABAAReceptors The Journal of Neuroscience. ,vol. 16, pp. 6648- 6656 ,(1996) , 10.1523/JNEUROSCI.16-21-06648.1996
A Calogero, γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone Fertility and Sterility. ,vol. 71, pp. 930- 936 ,(1999) , 10.1016/S0015-0282(99)00063-1
S. L. Erdö, B. Rosdy, L. Szporny, Higher GABA Concentrations in Fallopian Tube Than in Brain of the Rat Journal of Neurochemistry. ,vol. 38, pp. 1174- 1176 ,(1982) , 10.1111/J.1471-4159.1982.TB05368.X
Sándor L. Erdö, Ádám László, High Specific γ‐Aminobutyric Acid Binding to Membranes of the Human Ovary Journal of Neurochemistry. ,vol. 42, pp. 1464- 1467 ,(1984) , 10.1111/J.1471-4159.1984.TB02810.X
Eva Hedblom, Ewen F. Kirkness, A NOVEL CLASS OF GABAA RECEPTOR SUBUNIT IN TISSUES OF THE REPRODUCTIVE SYSTEM Journal of Biological Chemistry. ,vol. 272, pp. 15346- 15350 ,(1997) , 10.1074/JBC.272.24.15346
L. C. Kao, S. Tulac, S. Lobo, B. Imani, J. P. Yang, A. Germeyer, K. Osteen, R. N. Taylor, B. A. Lessey, L. C. Giudice, Global Gene Profiling in Human Endometrium during the Window of Implantation Endocrinology. ,vol. 143, pp. 2119- 2138 ,(2002) , 10.1210/ENDO.143.6.8885
Depu Zhang, Xiaowei Li, Ziming Yao, Chuanfei Wei, Nannan Ning, Jingxin Li, GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation Cancer Letters. ,vol. 348, pp. 100- 108 ,(2014) , 10.1016/J.CANLET.2014.03.006
Eriko Fujii, Synthia H. Mellon, Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy. Endocrinology. ,vol. 142, pp. 1770- 1777 ,(2001) , 10.1210/ENDO.142.5.8153