The Renin—Angiotensin System in Diabetic Cardiovascular Complications

摘要: The renin-angiotensin system (RAS) exerts a wide range of effects on cardiovascular homeostasis and blood pressure (BP) control. A large body clinical evidence has demonstrated that inhibition angiotensin II (Ang II, Aspl-Phe8) production by angiotensin-converting enzyme (ACE) inhibitors reduce the onset and/or progression renal (1, 2, 3, 4, 5, 6, 7), retinal (8,9), (5,9, 10, 11, 12) complications diabetes mellitus (DM). majority BP-lowering in vivo vascular ACE have been reproduced with AT1 receptor antagonists (13, 14, 15, 16, 17, 18), suggesting Ang II/AT1 pathway mediates most angiotensin’s adverse diabetes. Although RAS provides protective against both microvascular DM, actions regulation remain incompletely understood. This chapter will review interactions between associated insulin resistance disease (CVD).