The chymase-angiotensin system in humans: biochemistry, molecular biology and potential role in cardiovascular diseases.

摘要: Abstract Angiotensin I-converting enzyme (ACE) inhibitors are highly effective in the treatment of cardiovascular diseases. However, relationship among antihypertensive effects ACE inhibitors, inhibition and plasma angiotensin II levels is complex. During chronic therapy with inhibition, return to normal despite a continued effect. Recent studies show that conversion I tissues can proceed complete inhibition. In search for potential inhibitor-resistant II-forming activity human heart tissue, chymase was identified as major enzyme. primates, chymase-like localized number including heart, blood vessels lungs. Within mast cells endothelial sites synthesis storage chymase, but high level secreted also found cardiac interstitium, associated extracellular matrix. Mammalian chymases may be divided into two distinct structural groups, alpha beta. alpha-chymases, such specific efficient enzymes. beta-chymases, several rat mouse chymases, have broad substrate specificity like chymotrypsin do not form II. humans baboons only single chm gene alpha-subtype identified. By using an analogue selectively converted by ACE, functional chymase-dependent formation has recently been demonstrated conscious baboons.(ABSTRACT TRUNCATED AT 250 WORDS)