Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer : National surgical adjuvant breast and bowel project protocol B-27
作者： Harry D Bear , Stewart Anderson , Roy E Smith , Charles E Geyer Jr , Eleftherios P Mamounas
关键词: Medicine 、 Chemotherapy 、 Urology 、 Surgery 、 Adjuvant 、 Breast cancer 、 Cyclophosphamide 、 Nitrogen mustard 、 Tamoxifen 、 Hazard ratio 、 Docetaxel
摘要: Purpose This study was designed to determine the effect of adding docetaxel (T) preoperative doxorubicin and cyclophosphamide (AC) on breast cancer response rates disease-free survival (DFS) overall (OS). Patients Methods Women with operable (N = 2,411) were randomly assigned receive AC followed by surgery, T or surgery then T. Tamoxifen initiated concurrently chemotherapy. Median time for 2,404 patients follow-up 77.9 months. Results Addition did not significantly impact DFS OS. There trends toward improved addition The reduced incidence local recurrences as first events (P .0034). Preoperative T, but postoperative in who had a clinical partial after (hazard ratio [HR] 0.71; 95% CI, 0.55 0.91; P .007). Pathologic complete response, which doubled ...
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