Taxanes and Epothilones in Cancer Treatment

摘要: The discovery of compounds that bind and inhibit the function microtubules dates back many centuries. first compound to be used medicinally in humans, ultimately identified have anti-microtubule properties, was colchicine. Colchicine, extracted from plant Colchicum autumnale, administered humans with gout sixth century A.D. [1]. After it colchicine blocked cells metaphase, became an important tool study cell cycle mitosis [2].