Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans.

作者: L Gianni , C M Kearns , A Giani , G Capri , L Viganó

DOI: 10.1200/JCO.1995.13.1.180

关键词: MetabolismPaclitaxelPharmacologyPharmacodynamicsCancerChemotherapyMedicineToxicityPharmacokineticsDisposition

摘要: PURPOSE To characterize and model the disposition of paclitaxel in humans and define a pharmacodynamic relationships between paclitaxel disposition and its toxicity and efficacy. …

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