Ethanol extract and saponin of Platycodon grandiflorum ameliorate scopolamine-induced amnesia in mice

摘要: Abstract This study was carried out to examine the effects of ethanol extract (EXPG) and saponin (SAP) from Platycodon grandiflorum on scopolamine-induced amnesia in mice. Fifty male ICR mice were assigned five groups—normal (normal diet + saline), control diet + scopolamine), EXPG 0.2% diet + 0.2% EXPG + scopolamine), 0.5% diet + 0.5% SAP 0.02% diet + 0.02% SAP + scopolamine)—and fed each diet ad libitum. After 4 weeks feeding appropriate diet, scopolamine (1 mg/kg, i.p.) given 45 minutes before passive avoidance Morris water maze tasks. Both groups group exhibited significant amelioration as measured both task task. Moreover, acetylcholinesterase (AChE) activity levels thiobarbituric acid-reactive substance (TBARS) serum brain lower than those group. T...