Utilising Molecular Biological and Histopathological Techniques to Study the Dopaminergic System in Patients with Melancholia

摘要: Objective: To describe the rationale for investigating dopaminergic system in patients with melancholia by applying molecular biological (notably, situ hybridisation) and histopathological techniques postmortem brain tissue.Method: Relevant advances functional neuroanatomy of frontostriatal circuits, as well insights from clinical neuroimaging studies primary secondary depressive disorders, are presented. These integrated developments pharmacological characteristics dopamine receptor subtypes recognition their selective anatomical distribution.Results: Converging data basic neurosciences suggest that pathophysiology disorders characterised psychomotor phenomena, such melancholia, may involve dysregulation mechanisms within complex circuits.Conclusions: The key feature hybridisation is its capacity to test variations components d...