Variability of quantitative scintigraphic salivary indices in normal subjects

摘要: UNLABELLED Several quantitative measures of salivary uptake and discharge have been proposed recently in the scintigraphic evaluation xerostomia. We investigated scatter four time-activity curve C(TAC)-derived indices a group volunteer subjects who met extensive inclusionary exclusionary criteria normalcy. METHODS Thirty-one adult volunteers underwent dynamic scintigraphy with gustatory stimulation. Any candidates subjective xerostomia, conditions or medications associated dry mouth, gland enlargement pregnancy were excluded from study. All had normal oral exams, xerostomia scores unstimulated whole-mouth flow rates. After intravenous administration 99mTcO-4, was performed generation TACs derived regions interest centered about major glands cavity. At 45 min postinjection, hard lemon candy given for 15 as stimulus. The following functional calculated each gland: partitioned percentage (PP) total prestimulated activity, maximum net ratio (NUR) its time occurrence (TNUR) stimulated fraction (DF). RESULTS ranges observed: parotid PP, 22%-49%; submandibular 4%-31%; NUR, 2.2-16.0; 1.4-16.2; TNUR, 8-45 min; 2-45 DF, 20%-99%; 27%-98%. Every subject except one 91-yr-old man showed frequent periodic transfer activity rising TAC responded to CONCLUSION So-called may perform poorly xerostomic patients because effects simultaneous glandular trapping, uptake, possible vascular washout combine widen reference limits. Coordinated analysis cavity activities, index averaging better temporal resolution help improve diagnostic performance.