Patient-derived xenograft models for personalized medicine in colorectal cancer.

摘要: Establishing superior preclinical models is critical for translational cancer research owing to the high failure rates of novel therapeutics in clinical studies. Even though cell line-derived xenograft are easy create, they have numerous limitations since these do not represent distinctive features each patient adequately. To circumvent discrepancies between and tumors, patient-derived (PDX) been developed. These established through engraftment tissue from a patient's tumor into an immune-deficient mouse, which preserves cell-cell interactions microenvironment. Since PDXs precisely replicate intratumoral heterogeneity, range chemotherapeutic agents can be tested on individual tumors. Colorectal represents unique case demonstrate perspectives revealed by PDX surmount conventional ex vivo models. associated with drawbacks respect prediction outcomes, currently model choice investigations colorectal cancer. In current review, we provide overview methodology applications discuss issues advancement research.