Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities

摘要: The role of Th17 lymphocytes in immunopathogenic processes has been well established, but little is known about their basic cell features. In this study, we compared polarized Th1 and for key biological activities related to pathogenicity trafficking. lineages were derived from TCR-transgenic CD4 murine cells specific against hen egg lysozyme. When adoptively transferred into mice expressing lysozyme eyes, both induced ocular inflammation with slight differences histological pathology. PCR analysis revealed selective expression IFN-γ or IL-17 eyes recipients, respectively. Additionally, found differ three other activities: 1) inferior capacity trigger massive lymphoid expansion splenomegaly; 2) the proportion among infiltrating inflamed recipient declined rapidly, becoming a minority by day 7, whereas remained majority throughout period; 3) remarkable noted between certain surface markers. particular, reactivated expressed higher levels CD49d α4β7 (mucosal homing) vitro CXCR3 (Th1 trafficking) vivo. Reactivated Th17, however, αEβ7 (epithelial tissue CD38 (activation, maturation vitro, vivo CCR6 (lymphocyte trafficking). These data reveal that several influencing migration pathogenic behavior during inflammatory disease.