NK cells in the eye

摘要: Publisher Summary Tissues within the eye have a limited capacity to regenerate.Consequently, immune-mediated inflammation can devastating consequences for vision. However, anatomical, physiological and dynamic immunoregulatory processes limit responses eye—a phenomenon known as immune privilege. Immune privilege limits activities of both adaptive innate systems. Cells lining cornea retina fail express MHC class I molecules, making them vulnerable natural killer (NK) cell-mediated lysis. NKT cells are clearly important induction tolerance in survival corneal allografts. NK divergent roles microbial infections ocular surface autoimmune diseases interior eye. The pathogenesis HSVK is involves participation CD4+ T neutrophils. indirectly contribute by promoting migration neutrophils into HSV-infected cornea. By contrast, participate resolution Pseudomonas keratitis through their coordinated production IFN-γ, which activates enhances clearance bacteria from infected role intraocular unclear. Some reports suggest that necessary full development EAU, while other studies indicate EIU. Although recognize kill uveal melanoma vitro, presence MIF TGF-β AH vitreous body silences cell–mediated surveillance tumor. indeed an “immunological microcosm” wide array immunological be observed, including processes.