NKT cells: facts, functions and fallacies

作者: Dale I. Godfrey , Kirsten J.L. Hammond , Lynn D. Poulton , Mark J. Smyth , Alan G. Baxter

DOI: 10.1016/S0167-5699(00)01735-7

关键词:

摘要: The proposed roles of NK1.1(+) T (NKT) cells in immune responses range from suppression autoimmunity to tumor rejection. Heterogeneity these contributes the controversy surrounding their development and function. This review aims provide an update on NKT cell biology and, whenever possible, compare what is known about NKT-cell subsets.

参考文章(121)
H Huang, H Chen, W E Paul, NK1.1+ CD4+ T cells lose NK1.1 expression upon in vitro activation. Journal of Immunology. ,vol. 158, pp. 5112- 5119 ,(1997)
Luc Van Kaer, David C. Scherer, David C. Scherer, Isao Serizawa, Seokmann Hong, Nicolas Burdin, Yasuhiko Koezuka, Nagendra Singh, Mitchell Kronenberg, Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype Journal of Immunology. ,vol. 163, pp. 2373- 2377 ,(1999)
A Herbelin, M Papiernik, A Vicari, M C Leite-de-Moraes, F Machavoine, M Dy, J M Gombert, MHC class I-selected CD4-CD8-TCR-alpha beta+ T cells are a potential source of IL-4 during primary immune response. Journal of Immunology. ,vol. 155, pp. 4544- 4550 ,(1995)
A Herbelin, C Gouarin, S Hong, L Van Kaer, J F Bach, A Hameg, J M Gombert, IL-7 Up-Regulates IL-4 Production by Splenic NK1.1+ and NK1.1− MHC Class I-Like/CD1-Dependent CD4+ T Cells Journal of Immunology. ,vol. 162, pp. 7067- 7074 ,(1999)
Claude Carnaud, Albert Bendelac, Andrew Beavis, Olivier Donnars, Yasuhiko Koezuka, Se Ho Park, Daniel Lee, Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells Journal of Immunology. ,vol. 163, pp. 4647- 4650 ,(1999)
Shigeyoshi Itohara, Tetsu Kawano, Masaru Taniguchi, Yujiro Tanaka, Hitoshi Nishimura, Yoshikazu Naiki, Yasunobu Yoshikai, Regulatory Role of Peritoneal NK1.1+αβ T Cells in IL-12 Production During Salmonella Infection Journal of Immunology. ,vol. 163, pp. 2057- 2063 ,(1999)
B Foster, C Prussin, TCR V alpha 24 and V beta 11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation. Journal of Immunology. ,vol. 159, pp. 5862- 5870 ,(1997)
G. Gonzalez-Aseguinolaza, C. de Oliveira, M. Tomaska, S. Hong, O. Bruna-Romero, T. Nakayama, M. Taniguchi, A. Bendelac, L. Van Kaer, Y. Koezuka, M. Tsuji, α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 8461- 8466 ,(2000) , 10.1073/PNAS.97.15.8461
Sylviane Pied, Jacques Roland, Anne Louise, Danièle Voegtle, Valérie Soulard, Dominique Mazier, Pierre-André Cazenave, Liver CD4−CD8−NK1.1+TCRαβ Intermediate Cells Increase During Experimental Malaria Infection and Are Able to Exhibit Inhibitory Activity Against the Parasite Liver Stage In Vitro The Journal of Immunology. ,vol. 164, pp. 1463- 1469 ,(2000) , 10.4049/JIMMUNOL.164.3.1463
Defu Zeng, Mi-Kyeong Lee, James Tung, Andrea Brendolan, Samuel Strober, Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice Journal of Immunology. ,vol. 164, pp. 5000- 5004 ,(2000) , 10.4049/JIMMUNOL.164.10.5000