Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.

摘要: Several apolipoproteins are known to be closely associated with amyloid fibrillogenesis. Serum A, apolipoprotein (apo) AII and apo A1 each deposited as biochemically distinct forms of amyloid. Late-onset Alzheimer's disease is linked one isotype E, E4. Apo E E4 in particular have been shown modulate fibril formation by amyloid-beta peptides vitro. Furthermore, the carboxy terminus has a constituent plaque We show immunohistochemically electron microscopically presence senile plaques. The intact can itself form amyloid-like fibrils vitro that Congo Red positive. propose some proteins when misfolded propagate this misfolding identical units, either autocatalytically or other induced fold into same abnormal conformation. This conformational mimicry may initiate and/or augment fibrillogenesis disease.