Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
作者： Eerdunbayaer , Mohamed Orabi , Hiroe Aoyama , Teruo Kuroda , Tsutomu Hatano
DOI: 10.3390/MOLECULES19043883
关键词: Enterococcus 、 Microbiology 、 Glycyrrhiza uralensis 、 Glycycoumarin 、 Bacteria 、 Oxacillin resistance 、 Flavonoid 、 Chemistry 、 Vancomycin-resistant Enterococcus 、 Staphylococcus aureus
摘要: Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive the oxacillin resistance of MRSA, we further investigated effectiveness constituents vancomycin-resistant Enterococcus (VRE) bacteria, purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, identified their structures as demethylglycyrol (31) 5,7-di-O-methylluteone (32), respectively. Examination showed 3-arylcoumarins such licoarylcoumarin (9) glycycoumarin (26), 2-arylcoumarones gancaonin I (17), moderate to potent VRE strains used in this study.
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