Serum uric acid is a GFR-independent long-term predictor of acute and chronic renal insufficiency: the Jerusalem Lipid Research Clinic cohort study

摘要: Background. Kidney disease is commonly accompanied by hyperuricemia. However, the contribution of serum uric acid (SUA) to kidney injury debated. Our objective was assess long-term prediction renal failure SUA. Methods. Visit 2 participants in Jerusalem Lipid Research Clinic cohort with normal baseline function were followed for 24–28 years. SUA levels assessed associations acute (ARF) and chronic (CRF) as defined hospital discharge records, mortality, ascertained through linkage national population registry. Results. Among 2449 eligible (1470 men, 979 women aged 35–78 years 1976–79), positively linked male sex, creatinine components metabolic syndrome but lower smokers diabetic subjects. The 22- 25-year incidence hospital-diagnosed (145 first events, 67% CRF) 24- 28-year mortality (587 events) higher subject hyperuricemia (>6.5 mg/dL men >5.3 women, reflecting upper quintiles), independent covariates. Hyperuricemia conferred adjusted hazard ratios 1.36 (P = 0.003), 2.14 < 0.001) 2.87 0.003) CRF ARF, respectively. Conclusions. predicts all-cause independently demographic clinical These results lend support undertaking trials examine effect acid-lowering strategies on outcomes.