Can infections trigger alpha-synucleinopathies?

摘要: As synucleinopathies, Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that involve the spread of pathogenic alpha-synuclein (αSyn) throughout brain. Recent studies have suggested a role for αSyn as an antimicrobial peptide in response to PD- MSA-related infections peripheral tissues, including those respiratory, gastrointestinal, urogenital systems. In this chapter, we examine epidemiological experimental evidence microbial triggering alpha-synucleinopathies. We propose model how infectious triggers, conjunction with inflammatory, environmental, genetic facilitators, may result transfer strains from periphery brain, where they propagate spread. Finally, discuss future research challenges programs necessary clarify triggers PD MSA and, ultimately, prevent onset these by triggers.