Suppression of cellular immune responses by Candida albicans
作者： Rivas Espinoza , G Victor
DOI:
关键词: Suppressor 、 Mixed lymphocyte reaction 、 Cell 、 Prostaglandin 、 Yeast 、 Immunosuppression 、 Biology 、 Immune system 、 Candida albicans 、 Microbiology
摘要: approved: Redacted for privacy TUas J. Rogers Experimental infection of mice with Candida albicans leads to significant suppression cell mediated immune responses. We have characterized the nature this candida-induced formalin killed (FKCA) in yeast and mycelia' phase. Mice (BALB/c or C57B1/6J) treated FKCA exhibited a reduction T-cell mitogen-induced blastogenic response mixed lymphocyte reaction. Further work has shown that is due induction suppressor cells, these cells are capable significantly reducing cellular responses when lymphocytes from untreated mice. The responsible immunosuppression been identified as B-lymphocyte. function dependent on prostaglandin synthesis during stage. Cell-free supernatants cultures suppressive added cells. HPLC analysis cell-free confirmed presence prostaglandin, demonstrated 4 additional components activity. Suppression Cellular Immune Responses by
oregonstate.edu参考文章(72)
D Primi, L Hammarström, C I Smith, G Möller, Characterization of self-reactive B cells by polyclonal B-cell activators. Journal of Experimental Medicine. ,vol. 145, pp. 21- 30 ,(1977) , 10.1084/JEM.145.1.21
ChloéC. Musatti, Maria Thereza Rezkallah, Ernesto Mendes, Nelson F. Mendes, In vivo and in vitro evaluation of cell-mediated immunity in patients with paracoccidioidomycosis Cellular Immunology. ,vol. 24, pp. 365- 378 ,(1976) , 10.1016/0008-8749(76)90220-3
S. I. KATZ, DARIEN PARKER, J. L. TURK, B-cell suppression of delayed hypersensitivity reactions Nature. ,vol. 251, pp. 550- 551 ,(1974) , 10.1038/251550A0
Deborah A. Nickerson, Ramona A. Havens, Ward E. Bullock, Immunoregulation in disseminated histoplasmosis: Characterization of splenic suppressor cell populations Cellular Immunology. ,vol. 60, pp. 287- 297 ,(1981) , 10.1016/0008-8749(81)90270-7
ANIL N. JAYAWARDENA, BYRON H. WAKSMAN, Suppressor cells in experimental trypanosomiasis Nature. ,vol. 265, pp. 539- 541 ,(1977) , 10.1038/265539A0
MARC E. COLDYNE, Prostaglandins and the modulation of immunological responses. International Journal of Dermatology. ,vol. 16, pp. 701- 712 ,(1977) , 10.1111/J.1365-4362.1977.TB01887.X
R. Hurley, Acute Disseminated (Septicaemic) Moniliasis in Adults and Children Postgraduate Medical Journal. ,vol. 40, pp. 644- 653 ,(1964) , 10.1136/PGMJ.40.469.644
L. J. Wysocki, V. L. Sato, "Panning" for lymphocytes: a method for cell selection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 75, pp. 2844- 2848 ,(1978) , 10.1073/PNAS.75.6.2844
Terry A. Kupers, John M. Petrich, Ada W. Holloway, Joseph W.St. Geme, Depression of tuberculin delayed hypersensitivity by live attenuated mumps virus The Journal of Pediatrics. ,vol. 76, pp. 716- 721 ,(1970) , 10.1016/S0022-3476(70)80290-6
N. Simonetti, V. Strippoli, Pathogenicity of the Y form as compared to M form in experimentally induced Candida albicans infections Mycopathologia Et Mycologia Applicata. ,vol. 51, pp. 19- 28 ,(1973) , 10.1007/BF02141282