Immunoregulation in disseminated histoplasmosis: Characterization of splenic suppressor cell populations

摘要: Abstract Potent immunosuppressor cell activity was induced during the course of disseminated histoplasmosis in C3H/Anf mice. Spleen cells from infected mice severely suppressed primary antibody response vitro normal syngeneic spleen to both a T-dependent antigen (sheep red blood cells) and T-independent (trinitrophenyl-lipopolysaccharide) at Weeks 1 3 infection, respectively. Likewise, marked suppressor present within lymph nodes. In kinetic study, detected first on Day 2 increased maximum level 4 after inoculation Histoplasma capsulatum . Two populations express function this model. One population, identified as T cells, nonadherent nylon wool columns; its capacity abolished by anti-Thy reduced greatly low-dosage X-irradiation (500 R). Cells second population had macrophage-like properties; although poorly adherent plastic surfaces, they adhered columns could be removed suspensions carbonyl iron treatment; high-dosage (3000 R) mitomycin C treatment failed abrogate suppression these cells.