Potassium channels in pulmonary arterial hypertension.
作者： Olivier Boucherat , Sophie Chabot , Fabrice Antigny , Frédéric Perros , Steeve Provencher
DOI: 10.1183/13993003.00798-2015
关键词: Signal transduction 、 Smooth muscle 、 Vasoconstriction 、 Thrombosis 、 Medicine 、 Vascular tone 、 Pulmonary artery 、 Cardiology 、 Pathology 、 Potassium channel 、 Internal medicine 、 Pathogenesis
摘要: Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with various origins. All forms of PAH share common pulmonary arteriopathy characterised by vasoconstriction, remodelling the pre-capillary vessel wall, and in situ thrombosis. Although pathogenesis recognised as complex multifactorial process, there growing evidence that potassium channels dysfunction artery smooth muscle cells hallmark PAH. Besides regulating many physiological functions, reduced expression and/or activity have significant effects on establishment progression. This review describes molecular mechanisms consequences channel modulation. Special emphasis placed KCNA5 (Kv1.5) KCNK3 (TASK1), which are considered to play central role determining vascular tone may represent attractive therapeutic targets treatment
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