Tissue specific distribution of Epstein-Barr virus (EBV) BZLF1 gene variants in nasopharyngeal carcinoma (NPC) bearing patients.

摘要: Using EBV BNLF1 gene polymorphism, we have recently shown that, in NPC bearing patients, lymphocytes and tumor cells of the same individual were infected by different viruses. It appeared as a rule that infection was multiple strains these immunocompetent, HIV negative patients. Our data did not detect any evident association between particular variant. In present paper, extend our analysis to BZLF1 viruses sites Only two main variants identified. Despite this very weak polymorphism locus, results entirely confirm frequent occurrence multistrain infections presence from individual. However, contrast concerning gene, be cell type specific, one being associated mainly with epithelial or other lymphocytes. The possible reasons for distribution are discussed.