Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines.
作者： Miguel Viveiros , Leonard Amaral
DOI: 10.1016/S0924-8579(00)00343-5
关键词: Isoniazid 、 Mycobacterium tuberculosis 、 Biology 、 Ethambutol 、 Pharmacology 、 Tuberculosis 、 Rifampicin 、 Streptomycin 、 Drug resistance 、 Microbiology 、 Antibiotics
摘要: Phenothiazines have been shown to inhibit the in vitro growth of multi-drug resistant (resistant rifampicin and isoniazid) Mycobacterium tuberculosis (MDRTB). They considered as potential adjuvants regimens employing four or more antibiotics for management freshly diagnosed infections M. patients from areas known a high prevalence MDRTB. Chlorpromazine has enhance activity (except ethambutol) which is susceptible. This might result reduction dose some all employed without sacrificing integrity treatment. Chlorpromazine, thioridazine promethazine were streptomycin when used combinations at concentrations that are minimally effective separately against clinical strains two (poly-drug MTB). The phenothiazines had no effect on isoniazid poly-drug MTB.
elsevier.com
sci-hub.se 参考文章(15)
Isabel Portugal, M. Viveiros, L. Brum, J. Moniz-Pereira, P. Ferrinho, H. David, M. J. Covas, Outbreak of multiple drug-resistant tuberculosis in Lisbon: detection by restriction fragment length polymorphism analysis. International Journal of Tuberculosis and Lung Disease. ,vol. 3, pp. 207- 213 ,(1999)
Lung Disease, Global Tuberculosis Programme, Anti-tuberculosis drug resistance in the world : the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance WHO Global Tuberculosis Programme. ,(1997)
JETTE E. Kristiansen, BODIL Vergmann, The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria. Acta Pathologica Microbiologica Scandinavica Series B: Microbiology. ,vol. 94, pp. 393- 398 ,(2009) , 10.1111/J.1699-0463.1986.TB03073.X
Miguel Viveiros Bettencourt, Suzana Bosne-David, Leonard Amaral, Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis. International Journal of Antimicrobial Agents. ,vol. 16, pp. 69- 71 ,(2000) , 10.1016/S0924-8579(00)00199-0
Alfred J. Crowle, George S. Douvas, Mary H. May, Chlorpromazine: A Drug Potentially Useful for Treating Mycobacterial Infections Chemotherapy. ,vol. 38, pp. 410- 419 ,(1992) , 10.1159/000239036
P. Hemalata Reddy, Sastry S. Burra, P. Suryanarayana Murthy, Correlation between calmodulin-like protein, phospholipids, and growth inglucose-grown Mycobacterium phlei Canadian Journal of Microbiology. ,vol. 38, pp. 339- 342 ,(1992) , 10.1139/M92-057
Leonard Amaral, Jette E Kristiansen, Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies International Journal of Antimicrobial Agents. ,vol. 14, pp. 173- 176 ,(2000) , 10.1016/S0924-8579(99)00153-3
Nancy L. Wengenack, Smilja Todorovic, Lian Yu, Frank Rusnak, Evidence for Differential Binding of Isoniazid by Mycobacterium tuberculosis KatG and the Isoniazid-Resistant Mutant KatG(S315T) Biochemistry. ,vol. 37, pp. 15825- 15834 ,(1998) , 10.1021/BI982023K
A. N. CHAKRABARTY, C. P. BHATTACHARYA, SUJATA G. DASTIDAR, Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine. Apmis. ,vol. 101, pp. 449- 454 ,(1993) , 10.1111/J.1699-0463.1993.TB00133.X
L. Amaral, J. E. Kristiansen, L. S. Abebe, W. Millett, Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis Journal of Antimicrobial Chemotherapy. ,vol. 38, pp. 1049- 1053 ,(1996) , 10.1093/JAC/38.6.1049