Effects of Postmenopausal Estrogen Replacement on the Concentrations and Metabolism of Plasma Lipoproteins
作者： Brian W. Walsh , Isaac Schiff , Bernard Rosner , Louise Greenberg , Veronica Ravnikar
DOI: 10.1056/NEJM199110243251702
关键词: Lipoprotein 、 Endocrinology 、 Very low-density lipoprotein 、 Medicine 、 Transdermal 、 Placebo 、 Apolipoprotein B 、 Chemotherapy 、 Estrogen 、 Oral administration 、 Internal medicine
摘要: Abstract Background. Postmenopausal estrogen-replacement therapy may reduce the risk of cardiovascular disease, and this beneficial effect be mediated in part by favorable changes plasma lipid levels. However, effects on lipoprotein levels postmenopausal estrogens low doses currently used have not been precisely quantified, mechanism these is unknown. Methods. We conducted two randomized, double-blind crossover studies healthy women who had normal values at base line. In study 1, 31 received placebo conjugated (0.625 mg 1.25 per day), each treatment for three months. 2, nine placebo, oral micronized estradiol (2 transdermal (0.1 twice a week), six weeks. The metabolism very-low-density (VLDL) low-density (LDL) was measured endogenously labeling their protein component, apolipoprotein B. Resu...
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