Screening of Potential Small Volume Resuscitation Products Using a Severe Hemorrhage Sedated Swine Model

摘要: Abstract : Background: Small volumes of resuscitation products to sustain survival until definitive care are desired in extreme environments due limited resources. A severe controlled hemorrhage model sedated, sexually mature miniature swine has been developed evaluate these products. Valproic Acid (VPA) and Pentoxifylline (PTX) have suggested as potential for small volume following predominately anesthetized animal models. We evaluated the time VPA PTX model. Methods: Fifteen male weighing 41.1 2.9 kg were sedated hemorrhaged 60% estimated blood over 1 hr treated with one following: 1) at 400 mg/kg a 1.33 ml/kg 2 min (n=4); 2) 300 30 (n=3); 3) 50 4) saline vehicle (n=4). Survival times compared non-resuscitated historic controls (n=16). was determined from end hemorrhage/initiation treatment. Results: Median (95% CI) were: Control 55.7 (17.5 86) min; (400 mg/kg) 6 (4 8) (300 17.5 (12 24.5) 60.8 (21 75) 92 (15 180) min. No treatment increased there no significant differences percent among groups. Conclusion: In this unacceptable concentrations delivery rates used because early deaths. Considering that drugs FDA approved other indications lower doses present data suggest further investigation mechanisms involved warranted.