A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h.

摘要: An animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy. A standardized lung contusion, liver laceration lower leg fracture applied in 25 pigs. They underwent controlled haemorrhage either blood volume loss 45 % median arterial pressure (MAP) <30 mmHg/90 min (group L, n = 15) or 50 % an MAP <25 mmHg/120 min H, n = 10). Five non-traumatized pigs served as control C). Subsequently, treatment given observational period 48 h. Both trauma groups showed signs organ injury (heart rate, lactate). The frequency cardiopulmonary resuscitation (CPR) directly related to severity haemorrhagic (CPR—group L: 4 15 pigs, group H: 10 pigs; Respiratory failure—group 3 13, 9. There no difference mortality between groups. present data suggest that our reflects failure humans period. suggests experimental protocol