Complement Activation and Organ Damage After Trauma-Differential Immune Response Based on Surgical Treatment Strategy.

摘要: Background: The complement system is part of the innate immunity, activated immediately after trauma and associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, death multiply injured patients. aim study was to investigate activation in pigs as well its effects on heart vivo vitro. Moreover, impact reamed vs. non-reamed intramedullary nailing examined regard pigs. Materials Methods: Male received trauma, followed by femoral with/without prior conventional reaming. Systemic hemolytic activity (CH-50 AH-50) local cardiac expression C3a receptor, C5a receptors1/2, deposition fragments C3b/iC3b/C3c determined trauma. Human cardiomyocytes were exposed or analyzed regarding calcium signaling mitochondrial respiration. Results: increased within 6 h mediated via classical alternative pathway. Furthermore, correlated invasiveness fracture treatment. receptors for altered locally left ventricles. acted detrimentally human affecting their functionality respiration vitro. Conclusion: After an early triggered, vitro, leading complement-induced dysfunction. intensity might correlate Reaming canal contribute enhanced “second hit” response Consequently, choice treatment imply clinical outcome critically patients be therefore crucial survival.