Mechanism of Adenylate Cyclase Activation by Cholera Toxin: Inhibition of GTP Hydrolysis at the Regulatory Site

作者: D. Cassel , Z. Selinger

DOI: 10.1073/PNAS.74.8.3307

关键词: GTP PhosphohydrolasesCyclaseCholera toxinGrowth-hormone-releasing hormone receptorGTP'ChemistryCyclase activityGTPaseAdenylate kinaseBiochemistry

摘要: … It was thought that the differences between GTP and Gpp(NH)p as activators of the … and enhances the GTP-dependent adenylate cyclase activity. Furthermore,the effects of GTP on the …

参考文章(1)
Yoram Salomon, Constantine Londos, Martin Rodbell, A highly sensitive adenylate cyclase assay Analytical Biochemistry. ,vol. 58, pp. 541- 548 ,(1974) , 10.1016/0003-2697(74)90222-X