Effect of alpha-methyl-DL-tryptophan on tryptophan metabolism of Musca domestica L.
作者： G.A Lancaster , T.L Sourkes
DOI: 10.1016/0010-406X(69)90581-7
关键词: Musca 、 Drug metabolism 、 Tryptophan Metabolism 、 Biology 、 In vitro 、 Internal medicine 、 Alpha (ethology) 、 In vivo 、 Tryptophan 、 Endocrinology 、 Paper chromatography
摘要: 1. 1. The effect of alpha-methyl-dl-trytophan on tryptophan pyrrolase Musca domestica L. was studied in vitro and vivo. 2. 2. This analogue inhibits by a competitive mechanism. 3. 3. After intrathoracic administration alpha-methyltryptophan dose 0·1 μmole per animal (average 10 m-moles/kg), the activity is inhibited. Greatest inhibition occurs about 18 hr, residual still evident at 56 hr after injection. However, insufficient to affect significantly concentration xanthommatin eyes. 4. 4. Tryptophan whole-body M. has KM 4·6 × 10−3
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sci-hub.se 参考文章(16)
Morton Civen, W. Eugene Knox, The specificity of tryptophan analogues as inducers, substrates, inhibitors, and stabilizers of liver tryptophan pyrrolase. Journal of Biological Chemistry. ,vol. 235, pp. 1716- 1718 ,(1960) , 10.1016/S0021-9258(19)76869-0
J.F. Moran, T.L. Sourkes, Induction of Tryptophan Pyrrolase by α-Methyltryptophan and Its Metabolic Significance in Vivo Journal of Biological Chemistry. ,vol. 238, pp. 3006- 3008 ,(1963) , 10.1016/S0021-9258(18)51858-5
Olga Greengard, Philip Feigelson, The purification and properties of liver tryptophan pyrrolase. Journal of Biological Chemistry. ,vol. 237, pp. 1903- 1907 ,(1962) , 10.1016/S0021-9258(19)73956-8
A. Calvin Bratton, E.K. Marshall, A NEW COUPLING COMPONENT FOR SULFANILAMIDE DETERMINATION Journal of Biological Chemistry. ,vol. 128, pp. 537- 550 ,(1939) , 10.1016/S0021-9258(18)73708-3
Takehiko Tanaka, W. Eugene Knox, The nature and mechanism of the tryptophan pyrrolase (peroxidase-oxidase) reaction of Pseudomonas and of rat liver. Journal of Biological Chemistry. ,vol. 234, pp. 1162- 1170 ,(1959) , 10.1016/S0021-9258(18)98149-4
Seymour Kaufman, Studies on tryptophan pyrrolase in Drosophila melanogaster. Genetics. ,vol. 47, pp. 807- 817 ,(1962) , 10.1093/GENETICS/47.7.807
R. W. Fisher, THE IMPORTANCE OF THE LOCUS OF APPLICATION ON THE EFFECTIVENESS OF DDT FOR THE HOUSE FLY, MUSCA DOMESTICA L. (DIPTERA: MUSCIDAE) Canadian Journal of Zoology. ,vol. 30, pp. 254- 266 ,(1952) , 10.1139/Z52-024
Corrado Baglioni, Genetic control of tryptophan pyrrolase in Drosophila melanogaster and D. virilis Heredity. ,vol. 15, pp. 87- 96 ,(1960) , 10.1038/HDY.1960.60
Bertha K. Madras, Theodore L. Sourkes, Formation of respiratory 14CO2 from variously labeled forms of tryptophan-14C in intact and adrenalectomized rats Archives of Biochemistry and Biophysics. ,vol. 125, pp. 829- 836 ,(1968) , 10.1016/0003-9861(68)90521-3
Hans Lineweaver, Dean Burk, The Determination of Enzyme Dissociation Constants Journal of the American Chemical Society. ,vol. 56, pp. 658- 666 ,(1934) , 10.1021/JA01318A036