摘要: The present invention demonstrates for the first time that alpha-methyl-tryptophan is an inhibitor of enzyme indoleamine diooxygenase (IDO). includes use in methods modulating immune responses and treating cancer infections.
lens.org 参考文章(9)
Deborah Braun, Matthew Albert, Control of indoleamine 2,3 deoxygenase expression and activity ,(2005)
James B. Duhadaway, George C. Prendergast, William Malachowski, Alexander J. Muller, Novel methods for the treatment of cancer ,(2004)
Andrew Mellor, David Munn, Regulation of T cell-mediated immunity by tryptophan ,(2006)
Miodrag Radulovacki, David W. Carley, Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists ,(2006)
Muthusamy Thangaraju, Vadivel Ganapathy, Puttur Prasad, Inhibitors of the atb(0,+) transporter and uses thereof ,(2009)
Wei Chen, Bruce R. Blazar, Andrew Mellor, David Munn, Indoleamine 2,3-dioxygenase pathways in the generation of regulatory t cells ,(2007)
Andrew Mellor, David Munn, Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase ,(2004)
Theodore L. Sourkes, Alpha-methyltryptophan as a therapeutic agent. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 15, pp. 935- 938 ,(1991) , 10.1016/0278-5846(91)90020-2
G.A Lancaster, T.L Sourkes, Effect of alpha-methyl-DL-tryptophan on tryptophan metabolism of Musca domestica L. Comparative Biochemistry and Physiology. ,vol. 28, pp. 1435- 1441 ,(1969) , 10.1016/0010-406X(69)90581-7