Regulation of T cell-mediated immunity by tryptophan

摘要: A mechanism of macrophage-induced T cell suppression is the selective elimination tryptophan and/or increase in one or more metabolites within local macrophage microenvironment. Studies demonstrate that expression IDO can serve as a marker activation, and may play significant role allogeneic pregnancy therefore other types transplantation, inhibitors be used to activate cells enhance activation when are suppressed by pregnancy, malignancy virus such HIV. Inhibiting degradation (and thereby increasing concentration while decreasing metabolite concentration), supplementing concentration, addition to, place of, IDO. Similarly, (thereby, for example, activity, suppress cells. Although described particularly with reference regulation, instead manipulate concentrations, modulate activity high affinity transporter, administer degrading enzymes. Regulation further manipulated using cytokines colony stimulating factor, interferon gamma, alone combination antigen cytokines.