IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase
作者： Ursula Grohmann , Francesca Fallarino , Roberta Bianchi , Maria Laura Belladonna , Carmine Vacca
DOI: 10.4049/JIMMUNOL.167.2.708
关键词:
摘要: The outcome of dendritic cell (DC) presentation tumor and/or self peptides, including P815AB (a peptide murine mastocytoma cells) and NRP-A7 synthetic mimotope recognized by diabetogenic T cells), may depend on a balance between the activities immunogenic (CD8α−) tolerogenic (CD8α+) DC. By virtue their respective actions CD8− CD8+ DC, IL-12 IFN-γ have functionally opposing effects DC subset, IFN-γ-activated mediate that prevail over adjuvant activity We previously shown CD40 ligation abrogates potential an effect associated with impaired capacity CD40-modulated IFN-γ-treated to degrade tryptophan initiate apoptosis in vitro. report here IL-6 both replace (upon administration recombinant cytokine) (as assessed use neutralizing Abs) ablating includes down-regulation IFN-γR expression subset correlates reduced ability these cells metabolize
jimmunol.org 参考文章(54)
Paolo Puccetti, Maria L. Belladonna, Maria C. Fioretti, Carmine Vacca, Roberta Bianchi, Ursula Grohmann, Autocrine IL-12 Is Involved in Dendritic Cell Modulation Via CD40 Ligation Journal of Immunology. ,vol. 163, pp. 2517- 2521 ,(1999)
Pascale Chomarat, Jacques Banchereau, Jean Davoust, A. Karolina Palucka, IL-6 switches the differentiation of monocytes from dendritic cells to macrophages Nature Immunology. ,vol. 1, pp. 510- 514 ,(2000) , 10.1038/82763
Abdelaziz Amrani, Joan Verdaguer, Pau Serra, Sabrina Tafuro, Rusung Tan, Pere Santamaria, None, Progression of autoimmune diabetes driven by avidity maturation of a T-cell population Nature. ,vol. 406, pp. 739- 742 ,(2000) , 10.1038/35021081
Miriam Merad, Lawrence Fong, Jakob Bogenberger, Edgar G. Engleman, Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo Blood. ,vol. 96, pp. 1865- 1872 ,(2000) , 10.1182/BLOOD.V96.5.1865
Ursula Grohmann, Roberta Bianchi, Maria L. Belladonna, Silvia Silla, Francesca Fallarino, Maria C. Fioretti, Paolo Puccetti, IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α−Dendritic Cells Via Potentiation of the CD8α+Subset The Journal of Immunology. ,vol. 165, pp. 1357- 1363 ,(2000) , 10.4049/JIMMUNOL.165.3.1357
Jacques Banchereau, Ralph M. Steinman, Dendritic cells and the control of immunity Nature. ,vol. 392, pp. 245- 252 ,(1998) , 10.1038/32588
Brendan Hilliard, Elena B. Samoilova, Youhai Chen, Tzu-Shang T. Liu, Jennifer L. Horton, IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells Journal of Immunology. ,vol. 161, pp. 6480- 6486 ,(1998)
S Silla, F Fallarino, Thierry Boon, Catherine Uyttenhove, None, Enhancement by IL-12 of the cytolytic T lymphocyte (CTL) response of mice immunized with tumor-specific peptides in an adjuvant containing QS21 and MPL. European Cytokine Network. ,vol. 10, pp. 181- 189 ,(1999)
P Coulie, J Van Snick, C Uyttenhove, C Druez, Functional and biochemical characterization of mouse P40/IL-9 receptors. Journal of Immunology. ,vol. 145, pp. 2494- 2499 ,(1990)
W Ridgway, L Steinman, S Brocke, C Dinisco, D Dalton, I A Ferber, C G Fathman, C Taylor-Edwards, Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). Journal of Immunology. ,vol. 156, pp. 5- 7 ,(1996)