Chemokine receptor antagonists as therapeutic agents
作者： Stephen C. Peiper , David H. Munn , Andrew L. Mellor
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摘要: The present invention provides methods and compositions to reduce immune tolerance at specific sites. In one aspect, the comprises tumorigenicity. an embodiment, reduces recruitment of tolerance-inducing antigen presenting cells (APCs) or their precursors a tumor and/or draining lymph node by decreasing binding least tumor-associated ligand chemokine receptor on APCs APC precursors. is CCR6 mip-3α. another virus. virus HIV. further for development antibodies antagonists as therapeutic agents prevent tolerance.
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