A new approach to the determination of ethanol elimination rate in vivo: an extension of Widmark's equation.
作者： Herluf I. D. Thieden , Axel Hunding
DOI: 10.1111/J.1600-0773.1991.TB01207.X
关键词: Ethanol 、 Mean value 、 Toxicokinetics 、 Distribution Volume 、 Pitch factor 、 Peripheral compartment 、 Chemistry 、 Stereochemistry 、 Chromatography 、 In vivo 、 Initial distribution
摘要: In order to provide more experimental data about a single ethanol elimination sequence, tracer amounts of 14C-labelled were given intravenously in fed and fasted rats into preexisting pool unlabelled ethanol. The profiles the curves distinctly different from those This necessitated elaboration mathematical model based on two-compartment system, which by using early distribution phase linear part curve enables determination time-rate constants for ethanol, K12 K21 rate Q. It is shown that ratio K21'/(K21' + K12') "r", volume sense Widmark, K12' divided with Va (initial space ethanol) K21' Vb (the peripheral compartment). mean value +/- S.E.M. 0.57 0.05 0.49 0.03 fasted. slope time-concentration Widmark's beta, be K12'/(K12' x K21') Q where rate. 0.303 0.036 mmol l-1 min-1 0.219 0.015 min.-1 (P less than 0.05). concluded we are now able extend equation an independent factor "r".
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