Effect of varying concentration of ethanol on systemic hemodynamics and regional circulation.

摘要: Abstract The effect of ethanol (0.5 g/kg, IV) at different concentrations (30%, 60% and 90%) was studied in male cats using radioactive microspheres on systemic hemodynamics regional circulation. Ethanol produced a significant fall systolic, diastolic mean blood pressure. A reduction heart rate, left ventricular work, cardiac output total peripheral resistance also observed. No change occurred stroke volume. decrease flow to ventricle, right ventricle interventricular septum observed, but the vascular these regions unaltered. Brain not affected by various ethanol. significantly decreased spinal cord, medulla, pons, midbrain, hypothalamus, thalamus, caudate nucleus, cerebellum cortex. average brain (ml/min/100 g) 35.63 control, 37.17 30%, 35.56 35.05 90% ethanol-treated cats. Spleen, liver, pancreas, gastrointestinal tract, skin, muscle bone did show any flow, while organs. Kidneys eyes showed no following treatment. passing through arteriovenous shunts It is concluded that produces marked cardiovascular changes which are varying concentration