Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation

摘要: In vitro studies have demonstrated increased atherogenicity of oxidized low-density lipoprotein (ox-LDL) compared to native LDL. Oxidative modification LDL alters its structure allowing be taken up by scavenger receptors on macrophage, endothelial, and smooth muscle cells, leading the formation lipid-laden foam hallmark early atherosclerotic lesions. The susceptibility in oxidation was assessed essentially technique described Esterbauer et al. were monitored change 234-absorbance presence absence pure flavonoids. Morin, genistein, apigenin biochanin A, naringin quercetin used at different concentration. These flavonoids significantly inhibit oxidation, morin stronger inhibitory activity against than A or apigenin. This study show that prevent probably would important atherosclerosis.