Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties.

摘要: This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements other spectroscopic methods. These polymers aggregate weakly solution, but aggregates are broken down low shear forces or encapsulating a hydrophobic ligand within polymer. The small molecule these compared with those HSA. preliminary vitro paclitaxel studies showed very promising sustained drug characteristics achieved micelles.