Drug release characteristics of unimolecular polymeric micelles.
作者： Hongbo Liu , Stephanie Farrell , Kathryn Uhrich
DOI: 10.1016/S0168-3659(00)00247-9
关键词:
摘要: Biodegradable, unimolecular polymeric micelles possess several features that are attractive for drug delivery applications: Thermodynamic stability, ability to encapsulate and solubilize a hydrophobic guest molecule, biodegradability, as well size surface characteristics prevent rapid clearance by the RES. Here we investigate potential of these release an extended time. Lidocaine was used model in vitro studies using horizontal diffusion cell cellulose membrane prevented polymer transport from source receiver compartment. The free lidocaine under sink conditions zero-order complete within 8 h. initially encapsulated first 14 h, 96% detected 24
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sci-hub.se 参考文章(41)
IL Gyun Shin, So Yeon Kim, Young Moo Lee, Chong Soo Cho, Yong Kiel Sung, Methoxy poly(ethylene glycol)/ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin.: I. Preparation and characterization Journal of Controlled Release. ,vol. 51, pp. 1- 11 ,(1998) , 10.1016/S0168-3659(97)00164-8
Samuel H. Yalkowsky, Techniques of solubilization of drugs M. Dekker. ,(1981)
Lisbeth Illum, Stanley S. Davis, Polymers in Controlled Drug Delivery ,(1988)
A. T. Florence, David T. Attwood, Surfactant Systems: Their chemistry, pharmacy and biology ,(1983)
Susan E. Dunn, Anne Brindley, Stanley S. Davis, Martyn C. Davies, Lisbeth Illum, Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution. Pharmaceutical Research. ,vol. 11, pp. 1016- 1022 ,(1994) , 10.1023/A:1018939521589
So Yeon Kim, IL Gyun Shin, Young Moo Lee, Chong Su Cho, Yong Kiel Sung, METHOXY POLY(ETHYLENE GLYCOL) AND CAPROLACTONE AMPHIPHILIC BLOCK CO POLYMERIC MICELLE CONTAINING INDOMETHACIN. II: MICELLE FORMATION AND DRUG RELEASE BEHAVIORS Journal of Controlled Release. ,vol. 51, pp. 13- 22 ,(1998) , 10.1016/S0168-3659(97)00124-7
Tailored polymeric materials for controlled delivery systems American Chemical Society. ,(1998) , 10.1021/BK-1998-0709
A.V. Kabanov, V.P. Chekhonin, V.Yu. Alakhov, E.V. Batrakova, A.S. Lebedev, N.S. Melik-Nubarov, S.A. Arzhakov, A.V. Levashov, G.V. Morozov, E.S. Severin, V.A. Kabanov, The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting FEBS Letters. ,vol. 258, pp. 343- 345 ,(1989) , 10.1016/0014-5793(89)81689-8
J. Guo, S. Farrell, K. E. Uhrich, Interactions Between Unimolecular Micelles and Liposomes MRS Proceedings. ,vol. 550, pp. 89- ,(1998) , 10.1557/PROC-550-89
G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate) Langmuir. ,vol. 9, pp. 945- 949 ,(1993) , 10.1021/LA00028A012