Role of visceral proteins in detecting malnutrition in the elderly

作者: G Sergi , A Coin , G Enzi , S Volpato , E M Inelmen

DOI: 10.1038/SJ.EJCN.1602289

关键词: Body mass indexEndocrinologyInternal medicineTransferrinMalnutritionAlbuminRetinol binding proteinUnderweightProtein–energy malnutritionOverweightMedicine

摘要: In the clinical practice, visceral proteins are used as indirect markers of protein energy malnutrition (PEM), but their reliability could be reduced with advancing age. The aim this work is to investigate albumin, prealbumin, retinol-binding (RBP) and transferrin in evaluating nutritional status old patients relationship fat-free mass (FFM). Cross-sectional study. Padua, Italy. 44 underweight (body index<20 kg/m2) (66–97 years) 69 normal weight or overweight elderly subjects (62–98 years), RBP were determined plasma. Body composition particularly FFM was obtained by dual X-ray absorptiometry. also expressed index (FFMI) calculated divided height squared. Subjects affected acute illnesses inflammatory states excluded. Albumin, prealbumin mean values significantly lower subjects. No differences between two groups found for transferrin. Albumin resulted under range 55, 25 54% subjects, respectively. Transferrin's low about 40% all FFMI shows a significant correlation albumin (r: 0.52), 0.64) 0.57). found. Visceral proteins, except transferrin, seem useful indexes detecting elderly; still should carefully evaluated because they suggest poor status.

参考文章(36)
R Roubenoff, S B Heymsfield, J J Kehayias, J G Cannon, I H Rosenberg, Standardization of nomenclature of body composition in weight loss. The American Journal of Clinical Nutrition. ,vol. 66, pp. 192- 196 ,(1997) , 10.1093/AJCN/66.1.192
John Edgar Smith, Lynne M DeMoor, Caroline E Handler, Edna L Green, Steven J Ritter, THE COMPLEX BETWEEN RETINOL AND RETINOL-BINDING PROTEIN IS FORMED IN THE ROUGH MICROSOMES OF LIVER FOLLOWING REPLETION OF VITAMIN A-DEPLETED RATS Biochimica et Biophysica Acta. ,vol. 1380, pp. 10- 20 ,(1998) , 10.1016/S0304-4165(97)00122-0
Ian Janssen, Donald S. Shepard, Peter T. Katzmarzyk, Ronenn Roubenoff, The healthcare costs of sarcopenia in the United States Journal of the American Geriatrics Society. ,vol. 52, pp. 80- 85 ,(2004) , 10.1111/J.1532-5415.2004.52014.X
Hélène Payette, Ronenn Roubenoff, Paul F. Jacques, Charles A. Dinarello, Peter W. F. Wilson, Leslie W. Abad, Tamara Harris, Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. Journal of the American Geriatrics Society. ,vol. 51, pp. 1237- 1243 ,(2003) , 10.1046/J.1532-5415.2003.51407.X
M J Kergoat, B S Leclerc, C PetitClerc, A Imbach, Discriminant biochemical markers for evaluating the nutritional status of elderly patients in long-term care The American Journal of Clinical Nutrition. ,vol. 46, pp. 849- 861 ,(1987) , 10.1093/AJCN/46.5.849
S B Heymsfield, R Smith, M Aulet, B Bensen, S Lichtman, J Wang, R N Pierson, Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. The American Journal of Clinical Nutrition. ,vol. 52, pp. 214- 218 ,(1990) , 10.1093/AJCN/52.2.214
Andrew Myron Johnson, Low levels of plasma proteins: malnutrition or inflammation? Clinical Chemistry and Laboratory Medicine. ,vol. 37, pp. 91- 96 ,(1999) , 10.1515/CCLM.1999.017
T. Fuerst, H. K. Genant, Evaluation of body composition and total body bone mass with the hologic QDR-4500 Osteoporosis International. ,vol. 6, pp. 202- 202 ,(1996) , 10.1007/BF02500344
M. Bonnefoy, M. Jauffret, T. Kostka, J.F. Jusot, Usefulness of Calf Circumference Measurement in Assessing the Nutritional State of Hospitalized Elderly People Gerontology. ,vol. 48, pp. 162- 169 ,(2002) , 10.1159/000052836