L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA1.

摘要: AIM Adult neurogenesis occurs in two major niches the brain: subgranular zone of hippocampal formation and ventricular-subventricular zone. Neurogenesis both is reduced ageing neurological disease involving dementia. Exercise can rescue memory by enhancing neurogenesis, but whether exercise affects adult remains unresolved. Previously, we reported that induces angiogenesis through activation lactate receptor HCA1. The aim present study to investigate HCA1 -dependent effects on main neurogenic niches. METHODS Wild-type knock-out mice received high intensity interval exercise, subcutaneous injections L-lactate, or saline injections, five days per week for seven weeks. Well-established markers proliferating cells (Ki-67) immature neurons (doublecortin), were used RESULTS We demonstrated enhanced activation: Treatment with resulted increased wild-type, not mice. In zone, was induced genotypes, unaffected treatment. CONCLUSION Our demonstrates brain regulated differently: only activation. This opens a role physiological control potentially counteracting age-related cognitive decline.