The Clinical and Diagnostic Significance of Anti-myosin Autoantibodies in Cardiac Disease
作者： Udi Nussinovitch , Yehuda Shoenfeld
DOI: 10.1007/S12016-010-8229-8
关键词: Autoimmune heart disease 、 Rheumatic fever 、 Autoimmunity 、 Disease 、 Dilated cardiomyopathy 、 Heart disease 、 Myocarditis 、 Autoantibody 、 Immunology 、 Medicine
摘要: Autoimmunity is influenced by genetic, immune, hormonal, and environmental factors. Viral infections may trigger autoimmunity. It has been established that autoimmunity be a contributing factor in the pathogenesis of heart disease. Anti-heart autoantibodies have identified sera patients with diseases, as well low titers certain healthy individuals. Nevertheless, role humoral immunity development autoimmune disease not fully established. Anti-myosin appear several diseases such myocarditis, dilated cardiomyopathy, Chagas' disease, Kawasaki rheumatic fever, ischemic myocardium. The pathogenic anti-myosin understood. Moreover, little known concerning clinical implications its prognostic significance. Anti-cardiac myosin were found to cross-react β-adrenergic receptor. Studies reported effective use directed immune-modulating approach animals although no specific autoantibody therapeutic attempted humans. Herein, we review current knowledge targeted therapy different diseases.
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