Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use
作者： V.B. Kraus , F.J. Blanco , M. Englund , M.A. Karsdal , L.S. Lohmander
DOI: 10.1016/J.JOCA.2015.03.036
关键词: Intensive care medicine 、 Risk assessment 、 Risk stratification 、 Clinical trial 、 Physical therapy 、 Early disease 、 Osteoarthritis 、 Disease 、 Medicine 、 Terminology 、 Heterogeneous disorder
摘要: Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use standardized nomenclature for OA that could serve as building blocks describing and defining phenotypes, in short to provide unifying disease concepts disorder; (2) establishment ROAD (Risk Development) ROAP Progression) tools analogous the FRAX™ instrument predicting risk fracture osteoporosis; (3) formulation identifying its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive specific diagnostic criteria spur development modifying therapies entity has proved so recalcitrant date. We fully acknowledge we move forward, expect develop sophisticated definitions, terminology tools.
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