The neuronal correlates of mirror therapy: an fMRI study on mirror induced visual illusions in patients with stroke
作者： M. E. Michielsen , M. Smits , G. M. Ribbers , H. J. Stam , J. N. van der Geest
关键词: Optical illusion 、 Precuneus 、 Psychology 、 Posterior cingulate 、 Stroke 、 Premovement neuronal activity 、 Neuroscience 、 Illusion 、 Mirror neuron 、 Motor control 、 Physical medicine and rehabilitation
摘要: Aim To investigate the neuronal basis for effects of mirror therapy in patients with stroke. Methods 22 stroke participated this study. The authors used functional MRI to activation patterns two experiments. In unimanual experiment, moved their unaffected hand, either while observing it directly (no-mirror condition) or its reflection (mirror condition). bimanual both hands, affected hand place A two-factorial analysis movement (activity vs rest) and no mirror) as main factors was performed assess activity resultant illusion. Results Data on 18 participants were suitable analysis. showed a significant interaction effect movement×mirror during experiment. Activated regions precuneus posterior cingulate cortex (p Conclusion first study correlates illusion stroke, that movement, increases cortex, areas associated awareness self spatial attention. By increasing limb, might reduce learnt non-use. fact did not observe mirror-related motor neuron system questions popular theories attribute clinical these systems.
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