Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats
作者： Chun-Ching Lin , Den-En Shieh , Ming-Hong Yen
DOI: 10.1016/S0378-8741(97)00026-3
关键词: Toxicity 、 Galactosamine 、 Traditional medicine 、 Acetaminophen 、 Glycyrrhizin 、 Scutellaria 、 Pharmacognosy 、 Biochemistry 、 Medicine 、 Carbon tetrachloride 、 Ban-zhi-lian
摘要: Abstract The hepatoprotective effect of various fractions ( n -hexane, CHCl 3 , EtOAc, -BuOH, and H 2 O) Ban-zhi-lian derived from Scutellaria rivularis Benth. was studied against carbon tetrachloride (CCl 4 ), d -galactosamine -GalN) acetaminophen (APAP)-induced acute hepatotoxicity in rats. Liver damage assessed by quantifying serum activities glutamate oxaloacetate transaminase (sGOT) pyruvate (sGPT), as well histopathological examination. results indicated that the fraction EtOAc exhibited greatest effects on CCl -induced liver injuries, -hexane are most potent -GalN-induced intoxication, represented liver-protective APAP-induced hepatotoxicity. pathological changes hepatic lesions caused these three hepatotoxicants were improved treatment with mentioned above, which compared to Glycyrrhizin (GLZ) Silymarin standard reference medicines.
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sci-hub.se 参考文章(24)
K. Decker, D. Keppler, Galactosamine hepatitis: Key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death Reviews of Physiology Biochemistry and Pharmacology. pp. 77- 106 ,(1974) , 10.1007/BFB0027661
Hideki TSUJI, Sayoko OSAKA, Hiroshi KIWADA, Targeting of liposomes surface-modified with glycyrrhizin to the liver. I. Preparation and biological disposition. Chemical & Pharmaceutical Bulletin. ,vol. 39, pp. 1004- 1008 ,(1991) , 10.1248/CPB.39.1004
M Moore, H Thor, G Moore, S Nelson, P Moldéus, S Orrenius, The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. Journal of Biological Chemistry. ,vol. 260, pp. 13035- 13040 ,(1985) , 10.1016/S0021-9258(17)38834-8
R Rej, Aspartate aminotransferase activity and isoenzyme proportions in human liver tissues. Clinical Chemistry. ,vol. 24, pp. 1971- 1979 ,(1978) , 10.1093/CLINCHEM/24.11.1971
Richard O. Recknagel, Eric A. Glende, James A. Dolak, Robert L. Waller, Mechanisms of carbon tetrachloride toxicity Pharmacology & Therapeutics. ,vol. 43, pp. 139- 154 ,(1989) , 10.1016/0163-7258(89)90050-8
Shiro ISHIDA, Yoko SAKIYA, Tsutomu ICHIKAWA, Zenei TAIRA, Shoji AWAZU, Prediction of glycyrrhizin disposition in rat and man with liver failure by a physiologically based pharmacokinetic model. Journal of pharmacobio-dynamics. ,vol. 13, pp. 142- 157 ,(1990) , 10.1248/BPB1978.13.142
Hui-Fen Chiu, Chun-Ching Lin, Chui-Ching Yang, Fay Yang, The Pharmacological and Pathological Studies on Several Hepatic Protective Crude Drugs from Taiwan (I) The American Journal of Chinese Medicine. ,vol. 16, pp. 17- 23 ,(1988) , 10.1142/S0192415X88000194
Peter Moldéus, Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse Biochemical Pharmacology. ,vol. 27, pp. 2859- 2863 ,(1978) , 10.1016/0006-2952(78)90201-0
D. Keppler, K. Decker, Studies on the Mechanism of Galactosamine Hepatitis: Accumulation of Galactosamine‐1‐Phosphate and its Inhibition of UDP‐Glucose Pyrophosphorylase FEBS Journal. ,vol. 10, pp. 219- 225 ,(1969) , 10.1111/J.1432-1033.1969.TB00677.X
Chung-Chieng Wu, Min-Fen Chen, Chun-Ching Lin, Hui-Fen Chiu, Ming-Hong Yen, The pharmacological and pathological studies on Taiwan folk medicine (III): The effects of bupleurum kaoi and cultivated bupleurum falcatum var. komarowi. The American Journal of Chinese Medicine. ,vol. 18, pp. 105- 112 ,(1990) , 10.1142/S0192415X90000149