TRAIL gene expression analysis in multiple sclerosis patients

摘要: BACKGROUND: Multiple sclerosis (MS) as an autoimmune disorder in which the insulating covers of neurons Central Nervous System are destructed. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is immunomodulatory molecule to protect against T cells hyper activation. METHODS: In this Case-control study, we compare TRAIL gene expression peripheral blood between 50 relapse remitting MS patients and healthy controls by TaqMan Real time PCR. All were negative for HLA-DRB1*15 susceptible allele, normal serum vitamin D, responder Interferon beta. health individuals matched patients. Also, tried find correlation clinical characteristics RESULTS:No statistically significant difference was found mRNA ( p> 0.05). There no age onset, disease duration Expanded Disability Status Scale Kurtzke (EDSS). As IFN-b may have stimulatory effects on immunoregulatory function all our treated with interferon beta responder, it lead change expression. We suggest comparing responders non-responders should be investigated.