Down-regulation of CYP27B1 gene expression in Iranian patients with relapsing-remitting multiple sclerosis.
作者： Zahra Rezaie , Mohammad Taheri , Leila Kohan , Arezou Sayad
DOI: 10.3233/HAB-160297
关键词:
摘要: BACKGROUND Multiple sclerosis (MS) as a complex neurological disease can be due to vitamin D deficiency. CYP27B1 is referred metabolizing enzyme. MATERIALS AND METHODS This study compared the expression level of in Relapsing-Remitting MS (RRMS) patients with normal individuals Iran. The RNA was extracted from 50 RRMS and controls. Quantitative RT-PCR adopted measure gene. RESULTS CYP27B1gene significantly lower than their counterparts (P value = 0.04). Also, females participating had significant reduction gene (P-Value 0.01). In addition, correlation between level, risk Expanded Disability Status Scale Kurtzke (EDSS) not linear. Additionally, there no status duration disease. CONCLUSION A decrease CYP27A1 female could indicate greater vulnerability male patients.
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