Inhibition of 15-hydroxyprostaglandin dehydrogenase activity in rabbit gastric antral mucosa by panaxynol isolated from oriental medicines.
作者： Yohko Fujimoto , Satoru Sakuma , Sawako Komatsu , Daisuke Sato , Hiroko Nishida
DOI: 10.1111/J.2042-7158.1998.TB06925.X
关键词: IC50 、 Internal medicine 、 Enzyme inhibitor 、 Endocrinology 、 Prostaglandin E2 、 Arachidonic acid 、 Prostaglandin 、 Biology 、 Biological activity 、 Gastric mucosa 、 Dehydrogenase
摘要: Panaxynol is a polyacetylene compound with anti-inflammatory and anti-platelet-aggregatory effects isolated from commonly used oriental medicines. The of panaxynol on the activity prostaglandin-synthesizing catabolizing enzymes in rabbit gastric antral mucosa have been examined. At concentrations ranging 25 to 200 microM had no effect synthesis prostaglandins E2, F2alpha D2 exogenous arachidonic acid microsomal fraction whereas at 25-200 it dose-dependently inhibited 15-hydroxyprostaglandin dehydrogenase (PGDH), which catalyses initial step prostaglandin catabolism, cytosolic fraction. concentration required for 50% inhibition (IC50) was approximately microM. Inhibition PGDH by non-competitive regard NAD+ E2. These results suggest that has potential inhibit mucosa, possibly as result pharmacological activity.
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