Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor
作者： D. Yeboah , M. Sun , J. Kingdom , D. Baczyk , S.J. Lye
DOI: 10.1139/Y06-078
关键词: Cancer 、 Endocrinology 、 Internal medicine 、 Fetus 、 Syncytiotrophoblast 、 Blot 、 Fetal circulation 、 Biology 、 Placenta 、 Fetal membrane 、 Abcg2
摘要: Breast cancer resistance protein, BCRP, is a multidrug protein that highly expressed in the human placenta. In tissues, this actively extrudes wide variety of chemically and structurally unrelated chemotherapeutic drugs other compounds. Studies mice have shown absence BCRP activity placenta, there 2-fold increase uptake substrates into fetus. This suggests compounds would otherwise cross syncytiotrophoblast cells fetal circulation. The purpose study was to examine expression localization placenta throughout gestation. Tissues from 6–13, 16–19, 24–29, 32–35, 38–41 weeks gestation were used. Real time RT-PCR analysis demonstrated mRNA levels do not change significantly as progressed. However, Western blot revealed increased towards end We demon...
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