miR-342-3p suppresses cell proliferation and migration by targeting AGR2 in non-small cell lung cancer.
作者： Xiaofeng Xue , Xiaoyan Fei , Wenjie Hou , Yajie Zhang , Liu Liu
DOI: 10.1016/J.CANLET.2017.10.024
关键词: Phenotype 、 Proto-Oncogene Proteins c-akt 、 Biology 、 microRNA 、 AGR2 、 Lung cancer 、 Cell biology 、 Disease 、 Cell migration 、 Cell growth
摘要: AGR2 is a well-studied secreted protein that involved in multiple biological processes including cell proliferation and migration. The mechanism by which increases the growth migration of non-small lung cancer cells (NSCLC) still unknown. In this study, we report directly targeted miR-342-3p. Functional studies suggest overexpression miR-342-3p inhibits cells. Overexpression counteracts phenotypes induced Moreover, expression up-regulated negatively correlated with levels NSCLC tissues. A meta-analysis survival data indicates patients high their tumors have worse prognosis. Collectively, identification might facilitate development biomarkers therapeutic targets for devastating disease.
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