Fe2+-induced lipid peroxidation kinetics in liposomes: The role of surface Fe2+ concentration in switching the reaction from acceleration to decay
作者： Elena S. Driomina , Victor S. Sharov , Yury A. Vladimirov
DOI: 10.1016/0891-5849(93)90070-B
关键词: Kinetics 、 Chemiluminescence 、 Synthetic membrane 、 Membrane 、 Analytical chemistry 、 Lipid peroxidation 、 Ion 、 Liposome 、 Chromatography 、 Chemistry 、 Value (computer science)
摘要: Abstract Kinetics of malonyldialdehyde (MDA) accumulation, Fe2+ oxidation, and chemiluminescence (CL) at different initial iron ([Fe2+]) liposome ([L]) concentrations were measured in suspension. Above certain critical ([Fe2+]∗) the latent period (LP) LPO development was observed. The method [Fe2+]∗ estimation by dependence LP value (τ) on [Fe2+] elaborated. increase [L] resulted decrease τ ΔMDA as well SF CL amplitude. changed from 10 to 50 μM with change 1 4 mg/ml, so that ration [Fe2+]∗/[L] kept constant. This may be explained under assumption major part is bound membranes. At higher than one, chelators (desferrioxamine, o-phenantroline, EDTA) cations (Eu3+, Ca2+, Fe3+) decreased without any essential influence “slow flash” amplitude (h). Apparently, only result complexones ion concentration membrane surface. Thus, surface are main parameters determining both kinetics efficiency Fe2+-induced systems.
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